Clinical management of meningococcal disease

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PERSONAL PRACTICE Emergency management of meningococcal disease

Neisseria meningitidis is the leading infectious cause of death in childhood in the UK. 2 There were over 2500 cases and 246 deaths in 1997 and the disease has an overall mortality of about 10%. 5 Although mortality rises to 50% in the most severely ill patients, data from our unit suggests that early recognition, aggressive resuscitation, specialist advice, and transfer to paediatric intensive...

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The early management of meningococcal disease

Neisseria meningitidis is an important cause of bacterial meningitis, particularly in infants over three months old and in teenagers. The relative importance of meningococcal disease over invasive Haemophilus influenzae disease has increased following the introduction ofHib capsular vaccines in 1990. In about one fifth of infections with Neisseria meningitidis the organism causes a predominantl...

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The early management of meningococcal disease.

Meningococcal disease is a fulminant infection with an overall mortality of 8%. Mortality is significantly increased with meningococcal septicaemia, particularly when there has been a delay in the diagnosis. The trend from 1985 to 1995 has been an increase in incidence of this disease, and the relative importance of meningococcal disease has also increased following a fall in the incidence of i...

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Clinical presentation of meningococcal disease in childhood.

Although relatively rare, meningococcal disease represents a global health problem being still the leading infectious cause of death in childhood with an overall mortality around 8%. Meningococcal meningitis is the most commonly recognized presentation, accounting for 80% to 85% of all reported cases of meningococcal disease (in half of these cases sepsis is also present concomitantly). The rem...

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Meningococcal disease in children: a clinical review.

Meningococcal disease is a global burden and remains one of the leading infectious causes of death in children, with an estimated annual death rate of 170,000 worldwide. Despite these figures, the management of children with severe meningococcal sepsis and septic shock remains suboptimal. This review presents an overview of this condition including the epidemiology, pathogenesis, clinical manif...

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ژورنال

عنوان ژورنال: BMJ

سال: 1998

ISSN: 0959-8138,1468-5833

DOI: 10.1136/bmj.316.7136.1015